CURRICULUM VITAE
Specialties
Pharmacometrics, Population Pharmacokinetics & Pharmacodynamics,
Clinical Modeling & Simulation, Quantitative Pharmacology,
Model-informed Clinical Drug Development (MID3)
"Any sufficiently advanced technology is indistinguishable from magic."
Arthur C. Clarke
WORK EXPERIENCE
What I’ve Done
since February 2021
EXECUTIVE DIRECTOR & US HEAD, PHARMACOMETRICS
Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield CT, USA
Pharmacometrics team leader responsible for up to 6 internal and 3 external doctorate level direct reports, plus summer interns
Responsible for the development, implementation and execution of an integrated MID3 strategy across the global portfolio of the Therapeutic Area Inflammation
Accountable for the pharmacometrics deliverables in over 20 respiratory, immunology and inflammation projects, from start of clinical development to submission, registration, and beyond
Representation of pharmacometrics in internal & external advisory committees, the Therapeutic Area Strategy Team, strategic and operational working groups and initiatives, and regulatory meetings
Review and release of pharmacometric reports and other regulatory relevant documents
Administrative accountability for a group of 9 data science employees with an annual budget of approximately $3M (not including project / analysis budget)
June 2019 - January 2021
DIRECTOR, PHARMACOMETRICS / PRINCIPAL PHARMACOMETRICIAN
Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, USA
Matrix leadership of early clinical drug development teams in respiratory and immunology indications
Representation of Translational Medicine and Clinical Pharmacology in international project teams, and internal & external advisory committees
Representation of pharmacometrics in project and indication-level strategy teams, as well as regulatory meetings and initiatives (internal and external)
Participating in and leading of internal strategic and operational working groups in Global Pharmacometrics
Definition of appropriate pharmacometric analyses for internal decision making and successful approval (PMx strategy) on project and indication level
Performance of high quality pharmacometric analyses and interpretation of results
Authoring / co-authoring of pharmacometric reports and other regulatory relevant documents
Supervision of pharmacometric summer interns
October 2016 - May 2019
SENIOR ASSOCIATE DIRECTOR, PHARMACOMETRICS
Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, USA
Matrix leadership of early clinical drug development teams in respiratory and immunology indications
Representation of Translational Medicine and Clinical Pharmacology in international project teams
Representation of pharmacometrics in project teams and regulatory meetings and initiatives (internal and external)
Definition of appropriate pharmacometric analyses for internal decision making and successful approval (PMx strategy) on a project level
Performance of high quality pharmacometric analyses and interpretation of results
Authoring / co-authoring of pharmacometric reports and other regulatory relevant documents
Supervision of pharmacometric summer interns
April 2014 - September 2016
PHARMACOMETRICIAN
Model Answers Pty Ltd, Brisbane, Australia
Pharmacometric analyses as consultancy service to support clients’ decision making in drug development
Preparation of analysis plans, dataset specification files & analysis datasets, reports & presentations, and other relevant documentation for regulatory submission
Internal support for data analysts, trainees, and postgraduate students
Improvement of the company’s infrastructure of pharmacometric analysis tools, and development of code repositories for NONMEM, R and LaTeX
Contribution to the development of Model Answers Interactive, a suite of pharmacometric online simulation tools
February 2013 - March 2014 (fixed term)
POSTDOCTORAL RESEARCH FELLOW
Pharmacometrics Group, Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden
Project:
Model based, longitudinal meta-analyses of pharmacodynamic outcomes in the treatment of chronic obstructive pulmonary disease (COPD) with focus on decision making in clinical drug development.
Advisors:
Prof. M. O. Karlsson & Dr J. Ribbing
December 2012 - February 2013 (fixed term)
ASSISTANT RESEARCH FELLOW
Otago Pharmacometrics Group, New Zealand’s National School of Pharmacy, University of Otago, Dunedin, New Zealand
Project:
Development of a simplified mathematical model of the human physiome as basis for an electronic teaching tool for clinical pharmacology training (https://www.simpharm.com/)
Advisor:
Prof. S. B. Duffull
October 2012 - November 2012 (fixed term)
PHARMACOMETRICS INTERN
Model Answers Pty Ltd, Brisbane, Australia
Project:
Population pharmacokinetic-pharmacodynamic modelling of drug-induced QT prolongation.
Advisor:
A/Prof. B. Green
July 2009 - October 2012
TUTOR FOR UNDERGRADUATE PHARMACY COURSES
New Zealand’s National School of Pharmacy, University of Otago, Dunedin, New Zealand
Statistics, Physical Pharmacy, and Aseptic Dispensing
July 2006 - January 2009
COMMUNITY PHARMACIST
West-Apotheke, Lenzburg, Switzerland
Special Responsibilities:
Quality Management Representative
Implementation of a new Quality Management System
November 2005 - April 2006
PHARMACY INTERN
Central Hospital Pharmacy, Clinical Center Schwarzwald-Baar, Villingen-Schwenningen, Germany
Project:
Pediatric pain management (in German)
Advisor:
Dr E. Pallenbach
April 2005 - October 2006
PHARMACY INTERN
Schwarzwald Apotheke, Königsfeld im Schwarzwald, Germany
EDUCATION
What I’ve Learned
September 2009 - December 2012
Otago Pharmacometrics Group, New Zealand’s National School of Pharmacy, University of Otago, Dunedin, New Zealand
Thesis: Modelling red blood cell data
Supervisors: Prof. S. B. Duffull & A/Prof. L. K. Stamp
February 2009 - August 2009
POSTGRADUATE CERTIFICATE IN PHARMACY | PHARMACOMETRICS
Otago Pharmacometrics Group, New Zealand’s National School of Pharmacy, University of Otago, Dunedin, New Zealand
Thesis: A model for red blood cell survival time
Supervisor: Prof. S. B. Duffull
August 2006
REGISTERED PHARMACIST | GERMANY & SWITZERLAND
Drittes Pharmazeutisches Staatsexamen & Approbation
Spring 2005
STATE EXAMINATION IN PHARMACY | DISTINCTION FOR EXCELLENCE
Zweites Pharmazeutisches Staatsexamen
Albert-Ludwigs-University, Freiburg im Breisgau, Germany
Summer 2000
UNIVERSITY ENTRANCE DIPLOMA | DISTINCTION FOR EXCELLENCE
Abitur
Zinzendorf Gymnasium, Königsfeld im Schwarzwald, Germany
SOFTWARE & PROGRAMMING
What I Use
No matter the role or project, I’m confident in the skill set I bring to the table.
Take a look below to learn more about my specific software & programming abilities, and feel free to get in touch if you’d like to learn more.
PROGRAMMING
MATLAB; Perl;
R, RMarkdown, RStudio, Shiny
OPTIMAL DESIGN
PopED, PopED for R;
WinPopt, Popt
DOCUMENTS
LaTeX
Microsoft Office Excel, PowerPoint, Word
MODELLING & SIMULATION
MONOLIX; NONMEM;
Perl speaks NONMEM, Xpose
RECOGNITIONS
What I Achieved
PUBLICATION BURSARY
FOR PHD CANDIDATES
August 2012 - October 2012
University of Otago, Dunedin, New Zealand
PRESTIGIOUS PHD SCHOLARSHIP
August 2009 - July 2012
University of Otago, Dunedin, New Zealand
FINALIST | OMSRS PHD & MD STUDENT SPEAKER AWARDS
2010
The Otago Medical School Research Society, Dunedin, New Zealand
FINALIST | OTAGO INSTITUTE TRAVEL AWARD COMPETITION
2010
Otago Branch of the Royal Society of New Zealand, Dunedin, New Zealand
STUDENT SPEAKER AWARD PAGANZ
2010
Annual meeting of the Population Approach Group Australia and New Zealand, Adelaide, Australia
STUDENT SPEAKER RUNNER-UP ASCEPT NZ
2009
Annual scientific meeting of the Australasian Society for Clinical and Experimental Pharmacology and Toxicology - NZ Chapter, Dunedin, New Zealand
DISTINCTION FOR EXCELLENCE
STATE EXAMINATION IN PHARMACY
2005
Albert-Ludwigs-University,
Freiburg im Breisgau, Germany
DISTINCTION FOR EXCELLENCE UNIVERSITY ENTRANCE DIPLOMA
2000
Zinzendorf Gymnasium,
Königsfeld im Schwarzwald, Germany
WORKSHOPS
Where I Participated
2022
Pharmacometric Design and Power Analysis for Clinical Trials; Radboudumc Applied Pharmacometrics, WCoP virtual
2021
EXPOSURE Leadership Training; IESE, 3 months virtual training and coaching for executive leaders
TACA Training for Pharmacometric Statistics; Adrian Dunne, virtual
2019
nlmixr; Stockholm, Sweden
Strategic Thinking; Ridgefield CT, USA
Ambassador in Agility; Ridgefield CT, USA
2018
Early Clinical Development Team Leadership; Biberach an der Riß, Germany
2017
Delivering Effective Performance Feedback; Ridgefield CT, USA
Situational Leadership® II; Ridgefield CT, USA
GROW® Model InsideOut Development; Ridgefield CT, USA
Emotional Intelligence 2.0; Ridgefield CT, USA
Influencing without Authority; Ridgefield CT, USA
Simulo – Two-day Clinical Trial Simulation Course; SGS Exprimo, Budapest, Hungary
2016
Model-informed drug development, using the Simcyp population based PBPK/PD Simulator; Simcyp, Brisbane, Australia
2015
Emerging Leaders; Leadership Directions, Brisbane, Australia
New & Advanced Features of NONMEM 7.3; ICON, Hersonissos, Greece
Kinetic & Dynamic Complexity in Drug Transit-Response in the Human Body – Workshop on Modelling & Simulation; MD Pharmacon Pharmaceutical Services Ltd, Hersonissos, Greece
2014
Delays in Pharmacokinetics & Pharmacodynamics; Alicante, Spain
Lifespan Models; Intermediate Paws Course, PAGANZ 16, Dunedin, New Zealand | Contribution of lectures & hands-on exercises
2013
Decision Making in Clinical Drug Development; Uppsala University, Uppsala, Sweden | Contribution of a lecture on model based meta-analysis
Uppsala Pharmacometrics Summer School; Uppsala University, Uppsala, Sweden | Mentoring of group work & organisation of the social program
Basic Perl Programming for Biological Sciences; SciLifeLab, Uppsala University, Uppsala, Sweden
2012
Preparing for an Academic Career; Higher Education Development Centre,University of Otago, Dunedin, New Zealand | 10 week workshop with competitive entry
Sheiner Rowland Advanced Course in Pharmacokinetics & Pharmacodynamics; Sentosa Island, Singapore
2011
Phoenix NLME Workshop; Pharsight, Athens, Greece
ACADEMIC SERVICES & NON-PROFIT ACTIVITIES
Where I Contribute & Volunteer
EDITORIAL ADVISORY BAORD
Journal of Pharmacokinetics & Pharmacodynamics
AD-HOC REVIEWER
AAPS Journal
Biopharmaceutics & Drug Disposition
British Journal of Clinical Pharmacology
Clinical Pharmacology in Drug Development
Clinical Pharmacology & Therapeutics: Pharmacometrics & Systems Pharmacology
Dementia and Geriatric Cognitive Disorders
Journal of Pharmacokinetics & Pharmacodynamics
Journal of Pharmacology & Experimental Therapeutics
Pharmaceutical Research
Saudi Pharmaceutical Journal
ABSTRACT REVIEW COMMITTEE
American Conference on Pharmacometrics
MEMBER OF THE BOARD OF DIRECTORS
Westchester Oratorio Society, Katonah, NY | 2019 - 2022
MEMBERSHIPS & AFFILIATIONS
Where I Belong
ASCPT
American Society of Clinical Pharmacology & Therapeutics
DPHG
German Pharmaceutical Society | Deutsche Pharmazeutische Gesellschaft e.V.
ISOP
International Society of Pharmacometrics
PAGE
Population Approach Group in Europe
CCS
Connecticut Choral Society, Southbury, CT | Soprano
OCSB
The Oratory Choir of St. Boniface, Brooklyn, NY | Soprano
WOS
Westchester Oratorio Society, Katonah, NY | Soprano
MY PLACES
Where I Visited and Lived